This activity was originally presented at the 2025 ASHP Midyear Clinical Meeting & Exhibition.
Program Description
While chemoimmunotherapy has improved
outcomes for patients with non-Hodgkin lymphoma (NHL), a significant number of
patients relapse or have refractory disease. In the past several years,
bispecific antibodies (BsAbs) have emerged as an important therapeutic option
in NHL, with trials continuing to explore their use in earlier lines of
treatment. As new BsAb therapies receive FDA approval and are incorporated into
treatment guidelines, oncology pharmacists are crucial in navigating the complexities
of their safe and effective use. This program will provide a comprehensive
overview of BsAbs used in NHL, including their unique mechanism of action,
therapeutic targets, and clinical evidence in key NHL subtypes. Expert faculty
will share insights on the latest guideline-directed use of BsAbs, including in
combination regimens and for patients ineligible for CAR-T cell therapy.
Additionally, panelists will lead a case-based discussion focusing on
real-world challenges and pharmacist-driven solutions for BsAb integration,
including important topics such as therapy sequencing, site-of-care
coordination, and essential elements of patient education.
Target Audience: Managed care and health system pharmacists
Type
of Activity: Application
Release date: December 19, 2025
Expiration date: December 19, 2026
Learner level: Intermediate
Time to complete activity: 1.5 hour
Fee: Free
Educational Objectives
At the completion of this activity, participants will be able to:
- Explain the role of bispecific antibodies (BsAbs) in the management of non-Hodgkin lymphoma (NHL) based on emerging clinical data
- Apply key pharmacologic, clinical, and logistical factors to guide BsAb selection in NHL
- Analyze expert approaches to adverse effect prevention and intervention in the context of BsAb therapies
- Explore best practices for managing operational challenges related to BsAb implementation, including workflow design, resource utilization, and targeted education for patients and health care providers
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