Program Description
Complement-mediated kidney diseases (CMKDs) represent a complex and progressive group of rare kidney disorders stemming from the dysregulation of the immune system's complement cascade, leading to significant kidney damage. These conditions encompass distinct entities, each with unique pathophysiologies that require accurate differentiation for appropriate diagnosis and targeted therapeutic strategies. While traditional treatments like corticosteroids and immunosuppressants have been utilized, they often present challenges with adverse effects, variable patient responses, and a risk of relapse upon discontinuation. Treatment options are expanding beyond traditional steroids and immunosuppressants, with agents targeting specific areas of the complement pathway. Pharmacists play a crucial role in managing therapies for CMKDs by collaborating with multidisciplinary teams to educate on the latest guidelines and new and emerging treatments, managing drug interactions for complex comorbidities, and facilitating timely referrals for specialty care. Familiarity with new targeted treatments can reduce the burden of disease associated with CMKD, improving patient quality of life and reducing clinical burden. This program will provide pharmacists with essential strategies for counseling patients and caregivers on CMKDs, lifestyle modifications, medication adherence, and the safety and efficacy of new and emerging complement inhibitors for CMKD to optimize patient care.
Target audience: Ambulatory Care Pharmacist, Health System Pharmacist, Specialty Pharmacist
Type of activity: Application
Release date: August 22, 2025
Expiration date: August 22, 2026
Time to complete activity: 1.0 hour
Learner level: Foundational, Intermediate
Fee: Free
Educational Objectives
At the completion of this activity, participants will be able to:
- Explain the role of complement system dysregulation in complement-mediated kidney disease (CMKD) and its impact on disease progression, guiding pharmacologic interventions
- Analyze the safety, efficacy, and mechanisms of action of current and investigational complement inhibitors for CMKD, and customize appropriate therapy based on patient-specific factors
- Identify pharmacist-driven interventions to improve adherence, mitigate adverse effects, and enhance patient understanding of CMKD therapies
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