Program Description
Myeloproliferative neoplasms
(MPNs) are rare, chronic blood cancers arising from hematopoietic stem cells,
characterized by overproduction of myeloid cells. MPNs are often underdiagnosed
due to nonspecific symptoms, making molecular testing central to diagnosis and
treatment planning. Novel agents and combination strategies are continually
being investigated to address unmet needs, particularly for patients with
suboptimal responses or resistance to JAK inhibitors. Oncology pharmacists play
a critical role in precision medicine for MPNs, and their interventions require
familiarity with molecular mutation data, the ability to discern treatment
plans, and multidisiciplinary communication within the care team. They are
integral to the design and implementation of patient-specific management plans
for treatment-related toxicities, ensuring evidence-based supportive care is
planned and implemented promptly. This session will focus on MPN symptom
assessment, treatment algorithms, and emerging targeted therapies for MPNs to
inform the oncology pharmacist's role in precision medicine using molecular
data to guide treatment. This interactive session features patient case
examples that will review shared decision-making and considerations for
treatment of patients with MPNs.
Target Audience: Oncology Pharmacist
Type of Activity: Application
Release date: December
5, 2025
Expiration date: December
5, 2026
Learner
level: Foundational,
Intermediate
Time to complete activity: 1.0 hour
Fee: Free
Educational Objectives
At the completion of this activity, participants will be able to:
- Explain the clinical implications of common myeloproliferative neoplasm driver mutations and mechanisms of JAK/ BET/LSD1 inhibitors, combination regimens, and emerging targeted/precision therapies
- Use validated symptom scoring tools to recommend pharmacologic and nonpharmacologic treatments for common symptoms
- Employ strategies to help patients navigate challenges surrounding insurance approvals, financial support, and trial referrals
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