Two Targets, One Mission: Optimizing Bispecific Antibody Use in Non-Hodgkin Lymphoma

This activity was originally presented at the 2025 ASHP Midyear Clinical Meeting & Exhibition.

Program Description

While chemoimmunotherapy has improved outcomes for patients with non-Hodgkin lymphoma (NHL), a significant number of patients relapse or have refractory disease. In the past several years, bispecific antibodies (BsAbs) have emerged as an important therapeutic option in NHL, with trials continuing to explore their use in earlier lines of treatment. As new BsAb therapies receive FDA approval and are incorporated into treatment guidelines, oncology pharmacists are crucial in navigating the complexities of their safe and effective use. This program will provide a comprehensive overview of BsAbs used in NHL, including their unique mechanism of action, therapeutic targets, and clinical evidence in key NHL subtypes. Expert faculty will share insights on the latest guideline-directed use of BsAbs, including in combination regimens and for patients ineligible for CAR-T cell therapy. Additionally, panelists will lead a case-based discussion focusing on real-world challenges and pharmacist-driven solutions for BsAb integration, including important topics such as therapy sequencing, site-of-care coordination, and essential elements of patient education.

Target Audience: Managed care and health system pharmacists

Type of Activity: Application
Release date: December 19, 2025
Expiration date: December 19, 2026
Learner level: Intermediate
Time to complete activity: 1.5 hour
Fee: Free

Educational Objectives

At the completion of this activity, participants will be able to:

• Explain the role of bispecific antibodies (BsAbs) in the management of non-Hodgkin lymphoma (NHL) based on emerging clinical data
• Apply key pharmacologic, clinical, and logistical factors to guide BsAb selection in NHL
• Analyze expert approaches to adverse effect prevention and intervention in the context of BsAb therapies
• Explore best practices for managing operational challenges related to BsAb implementation, including workflow design, resource utilization, and targeted education for patients and health care providers

Pharmacy Times Continuing Education™ is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This activity is approved for 1.5 contact hours (0.15 CEU) under the ACPE universal activity number 0290-0000-25-418-H01-P. The activity is available for CE credit through December 19, 2026.

Instructions for Completing the Activity and Receiving CPE Credit

To receive CPE credit, participants must complete the pretest, view the activity in its entirety, complete the posttest, and complete the online activity evaluation. After successful completion of the online activity evaluation, you can submit your credit to CPE Monitor. You may view your credit within 48 hours at www.mycpemonitor.net. All participants must request credit before the activity expiration date. CE credit will not be issued after this date.

Disclosures

Shawn P. Griffin, PharmD, BCOP, has the following relevant financial relationships with ineligible companies to disclose:

Speakers Bureau: Geron

Robert Mancini, PharmD, BCOP, FHOPA, has the following relevant financial relationships with ineligible companies to disclose:

Consultant: GSK

Speakers Bureau: AbbVie/Genmab, Johnson & Johnson

The following contributors have no relevant financial relationships with ineligible companies to disclose:

Faculty

Breanna Taylor, PharmD, BCOP

Pharmacy Times Continuing Education™ Planning Staff—Jim Palatine, RPh, MBA; Dipti Desai, PharmD, MBA, CHCP; Kylie Ferrentino; Susan Pordon; Brianna Winters; and Chloe Taccetta

Any relevant financial relationships listed for these individuals have been mitigated.

At least one anonymous peer reviewer was used as part of content validation and conflict resolution. The peer reviewer has no relevant financial relationships with ineligible companies to disclose.

Educational Disclaimer

CPE activities are offered solely for educational purposes and do not constitute any form of professional advice or referral. Discussions concerning drugs, dosages, and procedures may reflect the clinical experience of the author(s) or they may be derived from the professional literature or other sources and may suggest uses that are investigational in nature and not approved labeling or indications. Participants are encouraged to refer to primary references or full prescribing information resources.

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