HER2 in Focus: Biomarker Insights and Therapeutic Advancements Across Solid Tumors

Program Description

Human epidermal growth factor receptor 2 (HER2) is an oncogenic driver that is prevalent across various solid tumors. Its overexpression or gene amplification leads to uncontrolled cell proliferation across solid tumor types, making it a key biomarker in precision oncology. This webinar provides a foundational understanding of HER2 pathobiology, its role in tumor cell growth, its prevalence, and its prognostic implications across key tumor types, including breast, gastrointestinal, gynecologic, genitourinary, and lung cancers. The core focus will be on evaluating the rapidly expanding landscape of current and emerging HER2-directed therapies. The mechanisms of action, FDA-approved indications, and recent clinical evidence for HER2-directed therapies, including monoclonal antibodies, tyrosine kinase inhibitors, antibody-drug conjugates, and bispecific antibodies, will be explored. This detailed pharmacological and clinical review will equip oncology pharmacists to effectively evaluate, select, and sequence HER2-targeted treatments in evolving clinical practice.

Target Audience: Health System Pharmacist, Oncology Pharmacist

Type of Activity: Application
Release date: December 19, 2025
Expiration date: December 19, 2026
Learner level: Intermediate
Time to complete activity: 1.0 hour
Fee: Free

Educational Objectives

At the completion of this activity, participants will be able to:

1. Explain the role of HER2 as a biomarker in the diagnosis and treatment of breast, gastrointestinal, gynecologic, genitourinary, and lung cancers, emphasizing its clinical relevance and prognostic implications.
2. Identify current and emerging HER2-directed therapies, including monoclonal antibodies, tyrosine kinase inhibitors (TKIs), antibody-drug conjugates (ADCs), and bispecific antibodies (BsAbs)
3. Analyze recent clinical evidence and advancements in HER2-targeted treatments

Pharmacy Times Continuing Education™ is accredited by the Accreditation Council for Pharmacy Education (ACPE) as a provider of continuing pharmacy education. This activity is approved for 1.0 contact hours (0.10 CEU) under the ACPE universal activity number 0290-0000-25-422-H01-P. The activity is available for CE credit through December 19, 2026.

Instructions for Completing the Activity and Receiving CPE Credit

To receive CPE credit, participants must complete the pretest, view the activity in its entirety, complete the posttest, and complete the online activity evaluation. After successful completion of the online activity evaluation, you can submit your credit to CPE Monitor. You may view your credit within 48 hours at www.mycpemonitor.net. All participants must request credit before the activity expiration date. CE credit will not be issued after this date.

Disclosures

The following contributors have no relevant financial relationships with ineligible companies to disclose:

Faculty

Bojana Stevich-Heemer, PharmD, PhD,

Pharmacy Times Continuing Education™ Planning Staff—Jim Palatine, RPh, MBA; Daphne Davis, PharmD, BCOP; Victoria Chirdo; Susan Pordon; Brianna Winters; and Chloe Taccetta have no relevant financial relationships with ineligible companies to disclose.

Any relevant financial relationships listed for these individuals have been mitigated.

At least one anonymous peer reviewer was used as part of content validation and conflict resolution. The peer reviewer has no relevant financial relationships with ineligible companies to disclose.

Educational Disclaimer

CPE activities are offered solely for educational purposes and do not constitute any form of professional advice or referral. Discussions concerning drugs, dosages, and procedures may reflect the clinical experience of the author(s) or they may be derived from the professional literature or other sources and may suggest uses that are investigational in nature and not approved labeling or indications. Participants are encouraged to refer to primary references or full prescribing information resources.

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